LifeSciences Lab Automation
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Download the NIH poster about BioRaptr 2.0 presented at SLAS 2023

Development and deployment of the BioRAPTR 2.0 FRD Dispenser through collaboration, and necessity, and evaluation of dispense and liquid handling technologies.

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The National Center For Advancing Translational Sciences (NCATS) has historically employed 1st generation BioRAPTR Flying Reagent Dispensers for offline assay validation/development and on our qHTS platforms. NCATS’ fleet of 1st generation BioRAPTRs were at end-of-life due to unsupported hardware and software. The need to maintain continuity and retain the functionality of the 1st generation BioRAPTRs prompted NCATS to seek out a vendor to undertake significant revamp to these devices. Let’s Go Robotics, Inc., in collaboration with NCATS, took on the task of retrofitting these 1st generation BioRAPTRs platforms with new internal electronics, controllers, software and GUI to create the BioRAPTR 2.0. Numerous software features were added beyond the 1st generation of BioRAPTRs. These include semi-auto volume scaling, multi-step dispense protocols, user access management, true column dispense, auto-calculated gradient dispenses, multiple liquid class calibrations stored on-board, backward compatibility with existing Excel based dispense definitions, simplified plate definition control widget, robot gripper compatible plate nest, droplet detection, among others. LGR has also added plate detection sensors and reporting to prevent crashes involving the dispenser tips, a common occurrence with the 1st generation BioRAPTRs. NCATS collaborated with LGR to perform in-lab testing of the software interface, mechanical performance and validation of dispense volumes across various liquid classes and plate types. Extensive testing and resulting feedback from benchwork completed at NCATS by staff engineers and scientists provided to LGR’s engineers and software developer further refined the hardware and software.

Image of NIH Poster about BioRaptr 2.0

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